SMC1A Antibody - Cat. #: CSB-PA614804ESR1HU

SKU: CSB-PA614804ESR1HU

Size :50ul

Clone Number:

Aliases:Chromosome segregation protein SmcB antibody; DXS423E antibody; KIAA0178 antibody; MGC138332 antibody; Sb1.8 antibody; Segregation of mitotic chromosomes 1 antibody; SMC protein 1A antibody; SMC-1-alpha antibody; SMC-1A antibody; SMC1 (structural maintenance of chromosomes 1 yeast) like 1 antibody; SMC1 antibody; SMC1 structural maintenance of chromosomes 1 like 1 antibody; SMC1A antibody; SMC1A_HUMAN antibody; SMC1alpha antibody; SMC1L1 antibody; SMCB antibody; Structural maintenance of chromosomes 1A antibody; Structural maintenance of chromosomes protein 1A antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q14683

Immunogen:Recombinant Human Structural maintenance of chromosomes protein 1A protein (1-130AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SMC1A

Research Areas:Epigenetics and Nuclear Signaling; Cell biology