SMARCA4 Antibody - Cat. #: CSB-PA021801KA01HU

SKU: CSB-PA021801KA01HU

Size :100ul

Clone Number:

Aliases:ATP dependent helicase SMARCA4 antibody; ATP-dependent helicase SMARCA4 antibody; BAF 190 antibody; BAF190 antibody; BAF190A antibody; Brahma protein like 1 antibody; BRG1 antibody; BRG1 associated factor 190A antibody; BRG1 protein antibody; BRG1-associated factor 190A antibody; BRM/SWI2 related gene 1 antibody; Global transcription activator homologous sequence antibody; global transcription activator snf2l4 antibody; Homeotic gene regulator antibody; hSNF2b antibody; Mitotic growth and transcription activator antibody; MRD16 antibody; Nuclear protein GRB1 antibody; Protein brahma homolog 1 antibody; Protein BRG-1 antibody; Protein BRG1 antibody; RTPS2 antibody; SMARC A4 antibody; SMARCA4 antibody; SMCA4_HUMAN antibody; SNF2 antibody; SNF2 beta antibody; SNF2 like 4 antibody; SNF2-beta antibody; SNF2B antibody; SNF2L4 antibody; SNF2LB antibody; Sucrose nonfermenting like 4 antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 4 antibody; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 antibody; SWI2 antibody; Transcription activator BRG1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P51532

Immunogen:A synthetic peptide of Human SMARCA4

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC; WB:1:500-1:2000, IHC:1:50-1:200

Background:The modulation of chromatin structure is an essential component in the regulation of transcriptional activation and repression. Modifications can be made by at least two evolutionarily conserved strategies, through the disruption of histone-DNA contacts by ATP-dependent chromatin remodelers, or by histone tail modifications including methylation and acetylation. One of the four classes of ATP-dependent histone remodelers is the SWI/SNF complex, the central catalytic subunit of which is Brg1 or the highly related protein hBRM. This SWI/SNF complex contains varying subunits but its association with either Brg1 or hBRM remains constant. SWI/SNF complexes have been shown to regulate gene activation, cell growth, the cell cycle and differentiation. Brg1/hBRM have been shown to regulate transcription through enhancing transcriptional activation of glucocorticoid receptors. Although usually associated with transcriptional activation, Brg1/hBRM have also been found in complexes associated with transcriptional repression including with HDACs, Rb and Tif1?. Brg1/hBRM plays a vital role in the regulation of gene transcription during early mammalian embryogenesis. In addition, Brg1/hBRM also play a role as a tumor suppressors and Brg1 is mutated in several tumor cell lines.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Affinity purification

Conjugate:Non-conjugated

Buffer:Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SMARCA4

Research Areas:Epigenetics and Nuclear Signaling?Neuroscience?Cancer;Stem cells