SIRPA Antibody - Cat. #: CSB-PA021334LA01HU

SKU: CSB-PA021334LA01HU

Size :50ug

Clone Number:

Aliases:Signal regulatory protein alpha type 1 antibody; Bit antibody; Brain Ig like molecule with tyrosine based activation motifs antibody; Brain Ig-like molecule with tyrosine-based activation motifs antibody; Brain immunoglobulin like molecule with tyrosine based activation motifs antibody; CD172 antigen like family member A antibody; CD172 antigen-like family member A antibody; CD172a antibody; CD172a antigen antibody; Inhibitory receptor SHPS-1 antibody; Macrophage fusion receptor antibody; MFR antibody; MYD 1 antibody; Myd 1 antigen antibody; MyD-1 antigen antibody; p84 antibody; Protein tyrosine phosphatase non receptor type substrate 1 antibody; PTPNS1 antibody; SHP substrate 1 antibody; SHPS-1 antibody; SHPS1 antibody; SHPS1_HUMAN antibody; Signal regulatory protein alpha 2 antibody; Signal regulatory protein alpha 3 antibody; Signal regulatory protein alpha antibody; Signal regulatory protein alpha type 2 antibody; Signal-regulatory protein alpha-1 antibody; Signal-regulatory protein alpha-2 antibody; Signal-regulatory protein alpha-3 antibody; SIRP antibody; Sirp-alpha-1 antibody; Sirp-alpha-2 antibody; Sirp-alpha-3 antibody; SIRPA antibody; SIRPalpha antibody; SIRPalpha1 antibody; SIRPalpha2 antibody; SIRPalpha3 antibody; Tyrosine phosphatase SHP substrate 1 antibody; Tyrosine protein phosphatase non receptor type substrate 1 antibody; Tyrosine-protein phosphatase non-receptor type substrate 1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P78324

Immunogen:Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1 protein (31-373AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background:Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SIRPA

Research Areas:Neuroscience; Cardiovascular; Signal transduction