SHIP2 (phospho-Tyr1135) rabbit pAb

SKU: ES13121

Size: 100μL

Source:Rabbit

Applications:WB;IF;ELISA;IHC

Reactivity:Human;Rat;Mouse;

Dilution:WB 1:500-2000; IF/ICC 1:50-200;ELISA 1:2000-20000;IHC-p 1:50-200

Immunogen:Synthesized phosho peptide around human SHIP2 (Tyr1135)

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):130kD

Human_gene_id:3636

Human_swiss_prot_no:O15357

Subcellular_location:Cytoplasm, cytosol . Cytoplasm, cytoskeleton. Membrane ; Peripheral membrane protein. Cell projection, filopodium . Cell projection, lamellipodium . Nucleus . Nucleus speckle . Translocates to membrane ruffles when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B). Tyrosine phosphorylation may also participate in membrane localization. Insulin specifically stimulates its redistribution from the cytosol to the plasma membrane. Recruited to the membrane following M-CSF stimulation. In activated spreading platelets, localizes with actin at filopodia, lamellipodia and the central actin ring.

Other_name:Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)

Background:The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009],