Sheep Interleukin-12 Subunit Beta, IL12B ELISA Kit

SKU: E0171Sh

Size:96 Tests-1 Kit

Background:Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).

Research_area:Immunology

Applications:ELISA

Target_protein:IL12B

Reactivity:Sheep

Assay type:Sandwich

Sensitivity:7.43ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interleukin-12 subunit beta

Species:Sheep

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P68220

MASS(Da):36,937

GeneID:443472

Synonyms:CLMF p40;Cytotoxic lymphocyte maturation factor 40 kDa subunit;IL-12;IL-12 subunit p40;IL12B;IL-12B;Interleukin-12 subunit beta

Gene names:IL12B

Standard solution:3200ng/L