Sheep Clusterin, CLU ELISA Kit

SKU: E0161Sh

Size:96 Tests-1 Kit

Background:Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity (By similarity). Following stress, promotes apoptosis (By similarity). Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (By similarity). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:CLU

Reactivity:Sheep

Assay type:Sandwich

Sensitivity:1.63ng/mL

Detection range:3-900ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Clusterin

Species:Sheep

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P17698

MASS(Da):7,659

GeneID:101113728

Synonyms:CLU;Clusterin;Clusterin alpha chain;Clusterin beta chain;Fragments;SGP-2;Sulfated glycoprotein 2

Gene names:CLU

Standard solution:960ng/mL