SHC1 Monoclonal Antibody

SKU: BT-MCA3526

Size:100μL

Background:This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

Research_area:Neuroscience

Target_protein:SHC1

applications:WB, ICC, FCM

Reactivity:Human, Mouse

Clonality:Monoclonal

Clone ID:2F7C7

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:SHC1

Immunogen:Purified recombinant fragment of human SHC1 (AA: 385-495) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide.

Concentration:

Molecular weight(Da):62.8kDa

UniProt accession:P29353

Synonyms:SHC, SHCA

GeneID:6464