Shc(Phospho-Ser239/240) Rabbit Polyclonal Antibody

SKU: BT-AP04726

Size:100μL

Background:This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways| the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms| p52Shc and p46Shc| link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms| p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

Research_area:Neuroscience; Signal transduction

Target_protein:SHC1

applications:WB

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Shc

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: P29353; Mouse: P98083; Rat: Q5M824

Synonyms:Shc ;Ser239/240; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1

GeneID:Human: 6464; Mouse: 20416; Rat: 85385