SH-PTP1 Polyclonal Antibody

SKU: E-AB-10587

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: PTPN6

Target Synonym: 70Z-SHP;EC 3.1.3.48;HCP;HCPH;Hematopoietic cell phosphatase;Hematopoietic cell protein tyrosine phosphatase;Hematopoietic cell protein-tyrosine phosphatase;HPTP1C;Protein tyrosine phosphatase 1C;Protein tyrosine phosphatase non receptor type 6;Protein tyrosine phosphatase SHP1;Protein-tyrosine phosphatase 1C;protein-tyrosine phosphatase SHP 1;Protein-tyrosine phosphatase SHP-1;PTN6;PTP 1C;PTP-1C;PTP1C;Ptpn6;SH PTP 1;SH PTP1;SH-PTP1;SHP 1;SHP 1L;SHP1;SHP1L;tyrosine protein phosphatase non receptor type 6;Tyrosine-protein phosphatase non-receptor type 6

Research Areas: Cancer;Cell Biology;Developmental Biology;Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse;Rat

Application: WB;IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: P29350

Accession:

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

Concentration: 0.3 mg/mL

Immunogen: Recombinant protein of human PTPN6

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Dilution: WB 1:200-1:1000;IHC 1:50-1:200

Calculated MW: 68kDa

ObservedMW: