SERPINA5 Antibody, FITC conjugated - Cat. #: CSB-PA021061LC01HU

SKU: CSB-PA021061LC01HU

Size :50ug

Clone Number:

Aliases:Acrosomal serine protease inhibitor antibody; IPSP antibody; IPSP_HUMAN antibody; PAI 3 antibody; PAI-3 antibody; PAI3 antibody; PCI antibody; PCI-B antibody; PLANH 3 antibody; PLANH3 antibody; Plasma serine protease inhibitor antibody; Plasminogen activator inhibitor 3 antibody; Plasminogen activator inhibitor III antibody; PROCI antibody; Protein C inhibitor antibody; Serpin A5 antibody; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 5 antibody; Serpin peptidase inhibitor clade A member 5 antibody; Serpina5 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P05154

Immunogen:Recombinant Human Plasma serine protease inhibitor protein (157-367AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SERPINA5

Research Areas:Cancer; Cardiovascular; Cell biology