SDHB Monoclonal Antibody

SKU: BT-MCA2432

Size:100μL

Background:Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

Research_area:Signal Transduction, Metabolism

Target_protein:SDHB

applications:IHC, FCM

Reactivity:

Clonality:Monoclonal

Clone ID:2E8B11

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:SDHB

Immunogen:Purified recombinant fragment of human SDHB (AA: 29-280) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):31.6kDa

UniProt accession:P21912

Synonyms:IP, SDH, CWS2, PGL4, SDH1, SDH2, SDHIP

GeneID:6390