SART3 Antibody, HRP conjugated - Cat. #: CSB-PA624010HB01HU

SKU: CSB-PA624010HB01HU

Size :50ug

Clone Number:

Aliases:DSAP1 antibody; hSART 3 antibody; hSART-3 antibody; P100 antibody; P110 antibody; p110(nrb) antibody; RP11 13G14 antibody; SART 3 antibody; SART-3 antibody; SART3 antibody; SART3_HUMAN antibody; Squamous cell carcinoma antigen recognized by T cells 3 antibody; Squamous cell carcinoma antigen recognized by T-cells 3 antibody; Tat interacting protein of 110 kDa antibody; Tat-interacting protein of 110 kDa antibody; Tip110 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q15020

Immunogen:Recombinant Human Squamous cell carcinoma antigen recognized by T-cells 3 protein (600-900AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SART3

Research Areas:Epigenetics and Nuclear Signaling; Cancer; Microbiology