RPS6KA5 (Ab-376) Antibody - Cat. #: CSB-PA144527

SKU: CSB-PA144527

Size :100ul

Clone Number:

Aliases:90 kDa ribosomal protein S6 kinase 5 antibody; EC 2.7.11.1 antibody; KS6A5_HUMAN antibody; MGC1911 antibody; Mitogen and stress activated protein kinase 1 antibody; MSPK1 antibody; Nuclear Mitogen And Stress Activated Protein Kinase 1 antibody; Nuclear mitogen- and stress-activated protein kinase 1 antibody; Ribosomal protein S6 kinase 90kD polypeptide 5 antibody; Ribosomal protein S6 kinase 90kDa antibody; Ribosomal protein S6 kinase 90kDa polypeptide 5 antibody; Ribosomal Protein S6 Kinase Alpha 5 antibody; Ribosomal protein S6 kinase alpha-5 antibody; RLPK antibody; RPS6KA5 antibody; RSK Like Protein Kinase antibody; RSK-like protein kinase antibody; RSKL antibody; S6K alpha 5 antibody; S6K-alpha-5 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O75582

Immunogen:Peptide sequence around aa.374~378 (G-Y-S-F-V) derived from Human MSK1.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).

Roux PP, et al. (2004) Microbiol Mol Biol Rev. Jun; 68(2): 320-344
McCOY C, et al. (2005) Biochem J. Apr 15; 387(Pt 2): 507-517

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RPS6KA5

Research Areas:Epigenetics and Nuclear Signaling;Cell biology;Metabolism;Signal transduction