ROBO3 Antibody - Cat. #: CSB-PA921768

SKU: CSB-PA921768

Size :50ul

Clone Number:

Aliases:FLJ21044 antibody; HGPPS antibody; HGPS antibody; RB inhibiting gene 1 antibody; Rbig 1 antibody; Rbig1 antibody; Retinoblastoma inhibiting gene 1 antibody; Rig 1 antibody; Rig1 antibody; Robo 3 antibody; Robo3 antibody; Robo3 protein antibody; ROBO3_HUMAN antibody; Roundabout axon guidance receptor homolog 3 antibody; Roundabout homolog 3 antibody; Roundabout like protein 3 antibody; Roundabout, axon guidance receptor, homolog 3 (Drosophila) antibody; Roundabout-like protein 3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q96MS0

Immunogen:Fusion protein of Human ROBO3

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, IHC; ELISA:1:2000-1:5000, IHC:1:25-1:100

Background:This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ROBO3

Research Areas:Neuroscience?Cancer;Signal transduction