RNF20 Antibody - Cat. #: CSB-PA736198LA01HU

SKU: CSB-PA736198LA01HU

Size :50ug

Clone Number:

Aliases:BRE1 A antibody; BRE1 antibody; BRE1 E3 ubiquitin ligase homolog antibody; BRE1-A antibody; BRE1A antibody; BRE1A_HUMAN antibody; E3 ubiquitin-protein ligase BRE1A antibody; hBRE1 antibody; Homolog of S. cerevisiae BRE1 antibody; RING finger protein 20 antibody; Ring finger protein 20 E3 ubiquitin protein ligase antibody; Rnf20 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q5VTR2

Immunogen:Recombinant Human E3 ubiquitin-protein ligase BRE1A protein (1-100AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of \\\'Lys-120\\\' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 \\\'Lys-4\\\' and \\\'Lys-79\\\' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RNF20

Research Areas:Cell biology