REST Antibody, FITC conjugated - Cat. #: CSB-PA019571LC01HU

SKU: CSB-PA019571LC01HU

Size :50ug

Clone Number:

Aliases:Neural Restrictive Silencer Factor antibody; Neural-restrictive silencer factor antibody; Neuron Restrictive Silencer Factor antibody; NRSF antibody; RE1 silencing transcription factor antibody; RE1-silencing transcription factor antibody; Repressor binding to the X2 box antibody; rest antibody; REST protein antibody; REST_HUMAN antibody; X2 box repressor antibody; XBR antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q13127

Immunogen:Recombinant Human RE1-silencing transcription factor protein (250-350AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:REST

Research Areas:Epigenetics and Nuclear Signaling; Neuroscience