Repetin rabbit pAb

SKU: ES4722

Size: 100μL

Source:Rabbit

Applications:WB;IHC

Reactivity:Human;Rat;Mouse;

Dilution:WB 1:500-2000;IHC-p 1:50-300

Immunogen:The antiserum was produced against synthesized peptide derived from human RPTN. AA range:648-697

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):90kD

Human_gene_id:126638

Human_swiss_prot_no:Q6XPR3

Subcellular_location:Secreted, extracellular space, extracellular matrix.

Other_name:RPTN; Repetin

Background:domain:Can be divided into a N-terminal domain with significant homology to S100-like calcium-binding proteins, a central domain containing a series of short tandem repeats, and two flanking segments with low homology to the consensus sequences of the central repeats.,function:Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Potential substrate of transglutaminase. Some arginines are probably converted to citrullines by peptidylarginine deimidase.,similarity:Belongs to the S100-fused protein family.,similarity:Contains 2 EF-hand domains.,tissue specificity:Expression is scattered in the normal epidermis but strong in the acrosyringium, the inner hair root sheat and in the filiform papilli of the tongue.,