RENALASE antibody , Cat. # FNab07239

SKU: FNab07239

Size:100ug

Purification:Protein A+G purification

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Mouse

Clonality:monoclonal

Clone ID:9C9

Isotype:IgG1

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:RNLS, also named as Renalase, C10orf59 and MAO-C, belongs to the renalase family. It is probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. RNLS degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. It lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. RNLS has physiologically relevant catecholamine-oxidizing activity.(PMID:15841207) This antibody is specific to RNLS.

Immunogen:chromosome 10 open reading frame 59

Synonyms:C10orf59, MAO C, Monoamine oxidase C, RENALASE, RNLS

Observed MW:38 kDa

Uniprot ID:Q5VYX0

Reactivity:Human

Tested Application:ELISA, WB, IHC

Recommended dilution:WB: 1:500-1:3000; IHC: 1:20-1:200

Gene ID:55328

Research Area:Cardiovascular, Metabolism