Recombinant Viral MIP-2 protein

SKU: CD00002

Size:10 ug

Background:Viral MIP-2 is one of the three chemokine-like proteins expressed by the human herpesvirus 8 (Kaposis sarcoma-associated herpesvirus, KSHV) and the other is ViMIP-1 and ViMIP-3. It shares 41 % and 48 % with human MIP-1α and ViMIP-1, respectively. ViMIP-2 has been shown to have antagonist activity towards a wide range of chemokine receptors and has functions of blocking infection by several different human immunodeficiency virus type 1 (HIV-1) strains. It may form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions. Additionally, ViMIP-2 has been shown to activate and chemoattract human eosinphils.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Viral Macrophage Inflammatory Protein-2

Biological activity:Fully biologically active when compared to standard. The specific activity is determined by the inhibitory effect on monocyte migration response to human MIP-1 alpha using a concentration range of 1.μg-1.μg/ml of viral MIP-2 will inhibit 25ng/ml of human MIP-1 alpha.

Synonyms:MIP-2, Viral

Endotoxin:Less than 1 EU/μg of rViMIP-2 as determined by LAL method.

Storage:-20ºC

Sequence:LGASWHRPDK CCLGYQKRPL PQVLLSSWYP TSQLCSKPGV IFLTKRGRQV CADKSKDWVK KLMQQLPVTA

uniprot accession:

Molecular weight:Approximately 8. kDa, a single, non-glycosylated polypeptide chain containing 7 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 mM PB, pH 7.4, 15mM NaCl.