Recombinant UCHL3 Monoclonal Antibody

SKU: AN300584P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:UCHL3

Target Synonym:RGD;UCHL;rCG_37146;RGD1561196;Uchl3

Research Areas:

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Rat

Application:WB;IHC-P;IP

Isotype:IgG

Clonality:Monoclonal

Clone NO.:11B5

UNIProt ID:Q91Y78

Accession:

Background:Ubiquitin carboxyl-terminal hydrolase isozyme L3, also known as UCH-L3, Ubiquitin thioesterase L3 and UCHL3, is a ubiquitin-protein hydrolase that belongs to the peptidase C12 family. It is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. UCHL3 is highly expressed in heart, skeletal muscle, and testis. UCHL1 and UCHL3 are two of the deubiquitinating enzymes expressed in the brain. These phenotypes indicate the importance of UCHL1 and UCHL3 in the regulation of the central nervous system. UCHL3 functions as a de-ubiquitinating enzyme where lack of its hydrolase activity may result in the prominent accumulation of ubiquitinated proteins and subsequent induction of stress responses in skeletal muscle. UCHL3 has also been identified as a tumor-specific antigen in colon cancer.

Concentration:1 mg/mL

Immunogen:Recombinant Rat UCHL3 protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:WB 1:500-1:2000;IHC-P 1:100-1:500;IP 1-4 μL/mg of lysate

Calculated MW:26 kDa

ObservedMW:31 kDa