Recombinant SDHB Monoclonal Antibody

SKU: AN301365L

Size::

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:SDHB

Target Synonym:PGL;CWS;SDHB;CWS2;IP;PGL4;SDH;SDH1;SDH2;SDHIP;PGL4;SDH;SDH1;SDH2;SdhB;SDHIP;DHSB;FLJ92337;homolog of;iron sulfur (Ip);Iron sulfur subunit;Iron sulfur subunit of complex II;Iron-sulfur subunit of complex II;mitochondrial;PGL 4;S. cerevisiae;SDH 1;subunit B;Succinate dehydrogenase [ubiquinone] iron sulfur protein mitochondrial;Succinate dehydrogenase [ubiquinone] iron sulfur subunit;Succinate dehydrogenase [ubiquinone] iron-sulfur subunit;Succinate Dehydrogenase 1 Iron Sulfur Subunit;Succinate Dehydrogenase 2;succinate dehydrogenase complex;Succinate dehydrogenase complex iron sulfur subunit B;Succinate dehydrogenase complex subunit B iron sulfur;Succinate Dehydrogenase Complex Subunit B Iron Sulfur Protein;Succinate dehydrogenase iron sulfur protein

Research Areas:Signal Transduction;Cell Biology;Cancer;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:4F12

UNIProt ID:P21912

Accession:

Background:Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human SDHB protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:2000-1:10000

Calculated MW:31 kDa

ObservedMW:31 kDa