Recombinant RIP Monoclonal Antibody

SKU: AN301086L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:RIP

Target Synonym:RIPK;RIP;RIP-1;RIP1;RIPK1;Cell death protein RIP;FLJ39204;OTTHUMP00000039163;Receptor (TNFRSF) interacting serine threonine kinase 1;Receptor interacting protein;receptor interacting protein 1;Receptor interacting protein kinase 1;Receptor interacting serine threonine protein kinase 1;Receptor TNFRSF interacting serine threonine kinase 1;Receptor-interacting protein 1;Receptor-interacting serine/threonine-protein kinase 1;Rinp;RIP 1;RIPK 1;Serine threonine protein kinase RIP;Serine/threonine-protein kinase RIP;RIPK1

Research Areas:Cell Biology;Signal Transduction;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:6G10

UNIProt ID:Q13546

Accession:

Background:ATP + a protein = ADP + a phosphoprotein.,Promotes apoptosis and activation of NF-kappa-B. Required for TNFRSF1A mediated activation of NF-kappa-B.,PTM:Autophosphorylated on serine and threonine residues.,PTM:Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation and enhances pro-apototic signaling through the TRADD-FADD interaction.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 death domain.,similarity:Contains 1 protein kinase domain.,subunit:Binds to the death domain of TNFRSF6 and TRADD. Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RIPK3, UBCE7IP1 isoform 3 (ZIN), EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interacts with MAVS/IPS1.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human RIP protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:IHC 1:200-1000;WB 1:1000-5000

Calculated MW:76 kDa

ObservedMW:76 kDa