Recombinant Rb Monoclonal Antibody

SKU: AN301387L

Size::

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:Rb

Target Synonym:PPP1R;OSRC;PPP1R130;RB;p105-Rb;pRb;pp110;RB1;Exon 17 tumor GOS561 substitution mutation causes premature stop;GOS563 exon 17 substitution mutation causes premature stop;Osteosarcoma;P105RB;PP105;Prepro retinoblastoma associated protein;Protein phosphatase 1 regulatory subunit 130;RB transcriptional corepressor 1;RB1 gene;retinoblastoma 1;Retinoblastoma protein;Retinoblastoma suspectibility protein;Retinoblastoma-associated protein

Research Areas:Cell Biology;Epigenetics and Nuclear Signaling;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:10A10

UNIProt ID:P06400

Accession:

Background:The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human Rb protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:2000-1:10000;

Calculated MW:106 kDa

ObservedMW:110 kDa