Recombinant Porcine IL-8/CXCL8 protein

SKU: CD00152

Size:2 ug

Background:Interleukin-8 (IL-8) is encoded by the IL8 gene and produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles. There are many receptors capable to bind IL-8, the most affinity to IL-8 are receptors CXCR1, and CXCR2. As a member of the CXC chemokine family, function of IL-8 is the induction of chemotaxis in its target cells, like neutrophil granulocytes, basophils, and T-cells. IL-8 is often associated with inflammation and has been cited as a proinflammatory mediator in gingivitis and psoriasis.

Research_area:Immunology

Purity:> 95 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Porcine Interleukin-8/CXCL8

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration range of 2-2 ng/ml.

Synonyms:IL-8/CXCL8, ,AMCF-I, IL8Porcine

Endotoxin:Less than 1 EU/ug of rPoIL-8/CXCL8 as determined by LAL method.

Storage:-20ºC

Sequence:ARVSAELRCQ CINTHSTPFH PKFIKELRVI ESGPHCENSE IIVKLVNGKE VCLDPKEKWV QKVVQIFLKR TEKQQQQQ

uniprot accession:P26894

Molecular weight:Approximately 9.1 kDa, a single non-glycosylated polypeptide chain containing 78 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 × PBS, pH 7.4.