Recombinant Phospho-eIF2α (Ser51) Monoclonal Antibody

SKU: AN301168L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Acetyl/Phospho/Methyl Antibodies;Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:eIF2α

Target Synonym:EIF2S;EIF;EIF-2;EIF-2A;EIF-2alpha;EIF2;EIF2A;EIF2S1;EIF 2;EIF 2 alpha;EIF 2A;EIF 2alpha;EIF2 alpha;eIF-2-alpha;Eukaryotic translation initiation factor 2 subunit 1;Eukaryotic translation initiation factor 2 subunit 1 alpha;Eukaryotic translation initiation factor 2 subunit 1 alpha 35kDa;Eukaryotic translation initiation factor 2 subunit alpha;IF2A

Research Areas:Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:12F6

UNIProt ID:P05198

Accession:

Background:The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).

Concentration:0.2 mg/mL

Immunogen:A synthetic peptide corresponding to residues around (Ser51) of Human Phospho-eIF2α

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:IHC 1:100-1:1000;WB 1:2000-1:10000

Calculated MW:36 kDa

ObservedMW:36 kDa