Recombinant Phospho-Cardiac Troponin I (Ser23, Ser24) Monoclonal Antibody

SKU: AN302104L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies;Acetyl/Phospho/Methyl Antibodies

Abbreviation:Phospho-Cardiac Troponin I (Ser23, Ser24)

Target Synonym:CMH;RCM;TNNI;TNNC;troponin I;TNNI3;CMD1FF;CMD2A;CMH7;RCM1;TNNC1;cTnI;troponin I3

Research Areas:Signal Transduction;Stem Cells;Cardiovascular;Developmental Biology

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A828

UNIProt ID:P19429

Accession:

Background:Cardiac troponin is composed of three subunits, namely cardiac troponin T (cTnT), cardiac troponin I (cTnI), and cardiac troponin C (cTnC).They collectively participate in the regulation of cardiac muscle contraction. The amino-terminal and carboxyl-terminal ends of cTnImolecules are prone to degradation through protein hydrolysis. Cardiac troponin I (cTnI) is an important regulatory factor that inhibits musclecontraction under normal circumstances. It binds to actin, preventing the interaction between actin and cardiac troponin C (cTnC), thusinhibiting muscle contraction. The phosphorylation status of cTnI can alter its affinity for actin, thereby influencing the regulation of musclecontraction. The serine residues at positions 22 and 23 of cTnI are susceptible to phosphorylation by protein kinase A, which regulatesmuscle contraction. Abnormal levels of phosphorylation may also contribute to muscle dysfunction or the development of heart disease.

Concentration:1 mg/mL

Immunogen:Peptide. This information is proprietary to PTMab

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:5000-1:10000

Calculated MW:24 kDa

ObservedMW:25 kDa