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GeneBio Systems

Recombinant PD1 Monoclonal Antibody

Recombinant PD1 Monoclonal Antibody

AN301420L

£302.00 GBP
£302.00 GBP
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Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:PD1

Target Synonym:SLEB;hSLE;Programmed Death;programmed cell death;Programmed cell death protein;Systemic lupus erythematosus susceptibility;hPD;PDCD1;CD279;PD-1;PD1;SLEB2;hPD-1;hPD-l;hSLE1;programmed cell death 1;PD 1;CD279 antigen;hPD 1;hPD l;PDCD 1;Programmed cell death 1 protein;Programmed Death-1;Protein PD 1;Protein PD-1;Systemic lupus erythematosus susceptibility 2;Programmed cell death protein 1;CD279;CD279 antigen;hPD 1;hPD l;hPD-1;hSLE1;PD 1;PD-1;PD1;PDCD 1;PDCD1;PDCD1;Programmed cell death 1;Programmed cell death 1 protein;Programmed cell death protein 1;Protein PD 1;Protein PD-1;SLEB2;Systemic lupus erythematosus susceptibility 2

Research Areas:Cell Biology;Immunology;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:IHC;IF

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A115

UNIProt ID:Q15116

Accession:

Background:The programmed cell death 1 protein (PD1) is an inhibitory receptor expressed on antigen activated T-cells that plays a critical role in the induction and maintenance of immune tolerance to self-antigens. Upon binding to its ligands CD274/PDCD1L1 (PD-L1) and CD273/PDCD1LG2 (PD-L2), PD1 is phosphorylated within its immunoreceptor tyrosine-based switch motif (ITSM), which facilitates the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2. PTPN11/SHP-2 then dephosphorylates key T-cell receptor (TCR) proximal signaling molecules, including ZAP70, PRKCQ/PKC theta and CD247/CD3 zeta, leading to the direct inhibition of T-cell activation. The PD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and evade destruction by the immune system, thereby facilitating tumor survival.

Concentration:1 mg/mL

Immunogen:Synthetic peptide derived from the human PD1 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:IHC 1:200-1:1000;IF 1:50

Calculated MW:

ObservedMW:

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