Recombinant p27 KIP 1 Monoclonal Antibody

SKU: AN301021L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:p27 KIP 1

Target Synonym:KIP;MEN;CDKN;Cyclin-Dependent Kinase Inhibitor p;P27KIP;p27 KIP;CDKN1B;CDKN4;KIP1;MEN1B;MEN4;P27KIP1;p27 KIP 1;Cyclin-Dependent Kinase Inhibitor 1B;Cyclin-Dependent Kinase Inhibitor p27;AA408329;AI843786;Cdki1b;CDKN 1B;CDKN 4;CDN1B;Cyclin Dependent Kinase Inhibitor 1B;Cyclin dependent kinase inhibitor p27;Cyclin-dependent kinase inhibitor 1B (p27;Cyclin-dependent kinase inhibitor p27 Kip1;KIP 1;Kip1);OTTHUMP00000195098;OTTHUMP00000195099;p27;p27 Kip1;P27-like cyclin-dependent kinase inhibitor;p27

Research Areas:Cell Biology;Epigenetics and Nuclear Signaling;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:3P8

UNIProt ID:P46527

Accession:

Background:This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).

Concentration:0.2 mg/mL

Immunogen:Recombinant Human p27 KIP 1 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:IHC 1:200-1:1000;WB 1:1000-1:5000

Calculated MW:27 kDa

ObservedMW:27 kDa