Recombinant p16 INK4A Monoclonal Antibody

SKU: AN300901L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:p16 INK4A

Target Synonym:INK;CMM;CDKN;P16INK;MTS;CDKN2A;ARF;CDK4I;CDKN2;CMM2;INK4;INK4A;MLM;MTS-1;MTS1;P14;P14ARF;P16;P16-INK4A;P16INK4;P16INK4A;P19;P19ARF;TP16;Cyclin-dependent kinase inhibitor 2A;CCM2;CDK4 inhibitor p16 INK4;Cell cycle negative regulator beta;Cyclin dependent kinase 4 inhibitor A;Cyclin Dependent Kinase Inhibitor 2A;Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4);Cyclin dependent kinase inhibitor 2A isoform 4;Cyclin dependent kinase inhibitor 2A isoforms 1/2/3;Cyclin dependent kinase inhibitor p16;Multiple tumor suppressor 1;p16

Research Areas:Cell Biology;Epigenetics and Nuclear Signaling;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:8C2

UNIProt ID:P42771

Accession:

Background:This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human p16 INK4A protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:1000-1:5000;

Calculated MW:17 kDa

ObservedMW:17 kDa