Recombinant NELF-B Monoclonal Antibody

SKU: AN302066L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:NELF-B

Target Synonym:KIAA;COBRA;NELFB;COBRA1;NELF-B;KIAA1182

Research Areas:Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:WB;IHC;FCM;IP

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A786

UNIProt ID:Q8WX92

Accession:

Background:NELF-B is an essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNApolymerase II. The NELF complex causes transcriptional pausing and is counteracted by the P-TEFb kinase complex. It may be able toinduce chromatin unfolding. NELF-B is a modulator of ligand dependent and independent expression of estrogen receptor-α target genes.NELF-B expression is reduced in metastatic and recurrent breast cancer, suggesting that low levels of NELF-B in breast cancers may serveas an indicator for poor prognosis.

Concentration:1 mg/mL

Immunogen:Peptide. This information is proprietary to PTMab.

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:10000-1:20000;IHC 1:100;FCM 1:100;IP 1:50-1:100

Calculated MW:66 kDa

ObservedMW:70 kDa