Recombinant Mouse GITR/TNFRSF18 Protein(Fc Tag)

SKU: PDMM100179

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Cytokines

Abbreviation:GITR/TNFRSF18

Target Synonym:Tumor necrosis factor receptor superfamily member;Tnfrsf;AITR;CD357;GITR-D;Glucocorticoid-induced TNFR-related protein;Tumor necrosis factor receptor superfamily member 18;Gitr;Tnfrsf18; GITR; AITR

Research Areas:

Conjugation:

Target Species:Mouse

Expression Host:Mammalian

Application:

Fusion tag:C-Fc

UNIProt ID:O35714

Accession:O35714

Background:GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.

Concentration:

Activity:Not validated for activity

Sequence:Gln20-His153

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW:39.6 kDa

ObservedMW:50 kDa