Recombinant Mouse Fetuin A/AHSG Protein(Fc Tag)

SKU: PDMM100139

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Others

Abbreviation:Fetuin A/AHSG

Target Synonym:KUB;SGP;TRPM;NA1/NA;A2HS;AHS;alpha-2-HS-glycoprotein;APOJ;APO-J;CLI;Countertrypin;Fetuin-A;HSGA;KUB1;NA1/NA2;SGP2;SP-40;TRPM2;Fetua;Ahsg

Research Areas:

Conjugation:

Target Species:Mouse

Expression Host:Mammalian

Application:

Fusion tag:C-Fc

UNIProt ID:P29699

Accession:P29699

Background:Fetuin-A , also known as Alpha-2-HS-Glycoprotein (AHSG) , belongs to the Fetuin family , is a plasma binding protein , and is more abundant in fetal than adult blood. It is involved in several functions , such as endocytosis , brain development and the formation of bone tissue. Fetuins are carrier proteins like albumin. Fetuin-A forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Thus Fetuin-A is a potent inhibitor of pathological calcification. The circulating levels of fetuin-A , a well-described inhibitor of calcification , regulate the cell-dependent process of osteogenesis. The low circulating fetuin-A levels are associated with a greater prevalence and/or severity of Vascular calcification (VC) and increased risk for all-cause and cardiovascular mortality. However , high circulating fetuin-A levels appear to induce insulin resistance and , in non-dialyzed subjects with diabetic nephropathy , are directly related to VC burden. The emerging role of fetuin-A deficiency as a risk factor in dialysis patients was documented in cross-sectional studies demonstrating a significant correlation with all-cause and cardiovascular mortality. Additionally , Human fetuin-A is a negative acute phase protein involved in inflammatory diseases , thus being a potential physiological regulator of meprin activity. Fetuin-A is a broad-range protease inhibitor. Fetuin-A and cystatin C as endogenous proteolytic regulators of meprin activity broadens our understanding of the proteolytic network in plasma.

Concentration:

Activity:Not validated for activity

Sequence:Ala19-Ile345

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW:57.6 kDa

ObservedMW:70-80 kDa