Recombinant Mouse Bcl-xL protein

SKU: CD00616

Size:2 ug

Background:Bcl-xL is a transmembrane protein located in the mitochondrial membranes of cells that are long-lived and postmitotic, such as adult brain cells. It plays a role in the signal transduction pathway of the FAS-Ligand. Bcl-xL is an anti-apoptotic protein which is a member of the Bcl-2 family which are able to form heterodimers, and this is an significant event in the regulation of apoptosis. It is involved in the survival of cancer cells. Bcl-xL is the leading monitor of apoptosis/active cell suicide. It has cell death repressor activity and therefore acts as a survival protein. The Mouse Bcl-xL shares 97 % and 99 % a.a. sequence identity with human and rat Bcl-xL, respectively.

Research_area: Cell Biology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Mouse B-cell lymphoma-extra large

Biological activity:Test in Process.

Synonyms:Bcl2l1, Bcl, Bcl(X, Bcl(X)L, Bcl-XL, Bcl2l, BclX, bcl-, bcl-x, bcl2-L-1, Mouse

Endotoxin:Less than 0.1 EU/μg of rMuBcl-xL as determined by LAL method.

Storage:-20ºC

Sequence:SQSNRELVVD FLSYKLSQKG YSWSQFSDVE ENRTEAPEET EAERETPSAI NGNPSWHLAD SPAVNGATGH SSSLDAREVI PMAAVKQALR EAGDEFELRY RRAFSDLTSQ LHITPGTAYQ SFEQVVNELF RDGVNWGRIV AFFSFGGALC VESVDKEMQV LVSRIASWMA TYLNDHLEPW IQENGGWDTF VDLYGNNAAA ESRKGQERFN R

uniprot accession: Q61337

Molecular weight:Approximately 23.7 kDa, a single non-glycosylated polypeptide chain containing 211 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 × PBS, pH 7.4, 5 % Trehalose.