Recombinant MMP-2 Monoclonal Antibody

SKU: AN300112P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies

Abbreviation:MMP2

Target Synonym:TBE;CLG;Matrix Metalloproteinase;MMP;CLG4;CLG4A;MMP-2;MMP-II;MONA;TBE-1;MMP2;72 kDa Gelatinase;72 kDa Type IV Collagenase;Gelatinase A;Matrix Metalloproteinase-2;72kD type IV collagenase;72kDa gelatinase;72kDa type IV collagenase);CLG 4;CLG 4A;Collagenase Type 4 alpha;Collagenase type IV A;Gelatinase alpha;Gelatinase neutrophil;Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase;Matrix Metalloproteinase 2;Matrix metalloproteinase 2 (gelatinase A;Matrix metalloproteinase II;MMP 2;MMP II;Neutrophil gelatinase;PEX;TBE 1

Research Areas:Cardiovascular;Cancer;Cell Biology;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB

Isotype:IgG

Clonality:Rabbit Monoclonal

Clone NO.:12F8

UNIProt ID:P08253

Accession:

Background:Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN), Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to a favorable prognosis in patients with a hormone receptor-negative tumor, usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity, MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems, including human breast cancer (HBC). Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment.

Concentration:1 mg/mL

Immunogen:Recombinant Human MMP-2 protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:WB 1:500-1:1000;

Calculated MW:73 kDa

ObservedMW:73 kDa