Recombinant MECP2 Monoclonal Antibody

SKU: AN300680L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:MeCP2

Target Synonym:BMP;MECP;MRXS;DKFZp686A;Methyl-CpG-binding protein;AUTSX;MRX;MECP2;AUTSX3;MRX16;MRX79;MRXS13;MRXSL;PPMX;RS;RTS;RTT;DKFZp686A24160;MeCp-2 protein;Methyl-CpG-binding protein 2;BMP7;OP1;AUTSX 3;Mbd 5;Mbd5;MECP 2;MeCP 2 protein;Methyl CpG binding protein 2;Methyl CpG binding protein 2 (Rett syndrome);MRX 16;MRX 79;MRXS 13;WBP 10;WBP10

Research Areas:Epigenetics and Nuclear Signaling;Neuroscience

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:6A1

UNIProt ID:P51608

Accession:

Background:DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human MECP2 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:IHC 1:200-1:1000;WB 1:2000-1:10000

Calculated MW:52 kDa

ObservedMW:75 kDa