Recombinant LysRS Monoclonal Antibody

SKU: AN301592L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:LysRS

Target Synonym:DFNB;KIAA;KARS;CMTRIB;DFNB89;KARS1;KARS2;KRS;EC 6.1.1.6;KARS 1;KARS 2;Lysine tRNA ligase;Lysine--tRNA ligase;LysRS;Lysyl-tRNA synthetase;SYK;KIAA0070

Research Areas:Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB;IHC;IF;IP

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A291

UNIProt ID:Q15046

Accession:

Background:Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA3(Lys), the primer for reverse transcription initiation.

Concentration:1 mg/mL

Immunogen:Recombinant human LysRS fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:1000;IHC 1:50-1:100;IF 1:50;IP 1:25-1:50

Calculated MW:75 kDa

ObservedMW:75 kDa