Recombinant IFNAR1 Monoclonal Antibody

SKU: AN300522P

Size::20μL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:IFNAR1

Target Synonym:Type I interferon receptor;Interferon alpha/beta receptor;IFN-R-1 IFN-alpha/beta receptor;Cytokine receptor class-II member;Cytokine receptor family 2 member;CRF2;CRF2-1;Cytokine receptor class-II member 1;Cytokine receptor family 2 member 1;IFN-R-1 IFN-alpha/beta receptor 1;Interferon alpha/beta receptor 1;Type I interferon receptor 1;Ifar;Ifnar;Ifnar1;Alpha type antiviral protein;alpha-type;Antiviral protein;AVP;Beta type antiviral protein;beta-type;CD118;IFN alpha REC;IFN alpha receptor;IFN alpha/beta Receptor alpha;IFN beta receptor;IFN Interferon-beta receptor;IFN-alpha/beta receptor 1;IFNBR;IFN-R-1;IFRC;INAR1;Infar;Interferon (alpha beta and omega) receptor 1;interferon alpha and beta receptor subunit 1;Interferon alpha/beta receptor alpha chain;Interferon beta receptor 1;interferon receptor 1;Interferon-alpha receptor

Research Areas:

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Mouse

Application:ICC/IF

Isotype:IgG

Clonality:Monoclonal

Clone NO.:9A10

UNIProt ID:P33896

Accession:

Background:Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant-negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.

Concentration:1 mg/mL

Immunogen:Recombinant Mouse IFNAR1 Protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:ICC/IF 1:20-1:100

Calculated MW:

ObservedMW: