Recombinant Human TWEAK Receptor protein

SKU: CD00748

Size:5 ug

Background:Human TNF-related weak inducer of apoptosis receptor (TWEAKR) also known as Tumor necrosis factor receptor superfamily member 12A precursor (gene name TNFRSF12A) or fibroblast growth factor-inducable 14 kDa protein, is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAK receptor can be activated by either the membrane anchored or the soluble TWEAK. In addition, It plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. Human and mouse TWEAK R share 82 % a.a. sequence identity.

Research_area:Immunology

Purity:> 95 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human TNF-related Weak Inducer of Apoptosis Receptor

Biological activity:Fully biologically active when compared to standard. The ED5 as determined by inhibiting TWEAK-dependent proliferation of human umbilical vein endothelial cells (HUVEC) is less than 3 ng/ml, corresponding to a specific activity of > 3.3 × 14 IU/mg, in the presence of 15 ng/ml of rHuTWEAK.

Synonyms:TWEAK Receptor,TNFSF12, CD266, FN14, TWEAKR,Human

Endotoxin:Less than 1 EU/μg of rHuTWEAK Receptor as determined by LAL method.

Storage:-20ºC

Sequence:EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP

uniprot accession:Q9NP84

Molecular weight:Approximately 5.6 kDa, a single non-glycosylated polypeptide chain containing 53 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in PBS, pH 7.4.