Recombinant Human TPP1/CLN2 Protein (His Tag)

SKU: PKSH033493

Size: 50μg

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: TPP1;CLN2

Target Synonym: CLN2;Cell Growth-Inhibiting Gene 1 Protein;GIG1;LPIC;Lysosomal Pepstatin-Insensitive Protease;SCAR7;TPP-1;TPP1;Tripeptidyl Aminopeptidase;Tripeptidyl-Peptidase 1

Research Areas: Cell biology;Neuroscience

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application:

Fusion tag: C-His

UNIProt ID: O14773

Accession: AAH14863.1

Background: Tripeptidyl-Peptidase 1 (TPP1) belongs to the peptidase S53 family. TPP1 is detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues. TPP1 is lysosomal serine protease with tripeptidyl-peptidase I activity. TPP1 may act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. TPP1 requires substrates with an unsubstituted N-terminus. TPP1 mutations have also been shown to cause neuronal ceroid lipofuscinosis type 2 (CLN2).

Concentration:

Activity: Not validated for activity

Sequence: Ser20-Pro563

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM CaCl₂, 10% Glycerol, pH 7.5.

Reconstitution: Not Applicable

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 60.4 kDa

ObservedMW: 74 kDa