Recombinant Human STING/TMEM173 Protein (Sumo & His Tag)

SKU: PKSH033517

Size: 50μg

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: STING;TMEM173

Target Synonym: Mediator of IRF3 activation;Stimulator of interferon genes protein;TMEM173;sting

Research Areas: Signal Transduction;Cancer;epigenetics and nuclear signal;immunology;

Conjugation:

Target Species: Human

Expression Host: E.coli

Application:

Fusion tag: N-SUMO-His

UNIProt ID: Q86WV6

Accession: Q86WV6

Background: Stimulator of Interferon Gene(Sting,TMEM173) belongs to the TMEM173 family. STING is 379 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-20), four transmembrane segments (aa 21-173), and a C-terminal cytoplasmic domain (aa 174-379). It ubiquitously expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophagesand. Its subunit structure associated with the MHC-II complex and Interacts with DDX58/RIG-I, MAVS and SSR2, RNF5 and TRIM56 along with TBK1. This type of protein often uses as facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon.

Concentration:

Activity: Not validated for activity

Sequence: Val155-Val341

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of 20mM HEPES, 100mM NaCl, 10% Glycerol, pH8.0.

Reconstitution: Not Applicable

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 33.8 kDa

ObservedMW: 35 kDa