Recombinant Human sCD163 Protein(His Tag)

SKU: PDMH100228

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Others

Abbreviation:sCD163

Target Synonym:C163A;CD 163;CD163;CD163 antigen;CD163 molecule;Hemoglobin scavenger receptor;M130;M130 antigen precursor;Macrophage associated antigen;MM130;OTTHUMP00000238617;OTTHUMP00000238618;OTTHUMP00000238619;OTTHUMP00000238620;SCARI1;Scavenger receptor cysteine rich type 1 protein M130;sCD163;Soluble CD163

Research Areas:Cancer;Cardiovascular;Immunology

Conjugation:

Target Species:Human

Expression Host:Mammalian

Application:

Fusion tag:C-His

UNIProt ID:Q86VB7

Accession:Q86VB7

Background:The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Concentration:

Activity:Not validated for activity

Sequence:Ser42-Ser1045

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW:110.3 kDa

ObservedMW:130-140 kDa