Recombinant Human RANTES/CCL5 protein

SKU: CD01008

Size:5 ug

Background:Chemokine (C-C motif) ligand 5 (CCL5) also known as RANTES is classified as a chemotactic cytokine or chemokine. It is encoded by the CCL5 gene in humans. CCL5 is chemotactic for T cells, eosinophils, and basophils, and plays an active role in recruiting leukocytes into inflammatory sites which has been reported to be produced by renal tubular epithelium, synovial fibroblasts and selected tumor cells. It also induces the proliferation and activation of certain natural-killer cells to form CHAK cells. Recombinant human CCL5 contains 68 amino acids and it shares 84 % a.a. sequence identity with Mouse and rat CCL5, respectively.

Research_area:Immunology

Purity:> 98 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Regulation upon Activation Normal T cell Express Sequence/CCL5

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 1.-1 ng/ml.

Synonyms:RANTES/CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP,Human

Endotoxin:Less than 1 EU/μg of rHuRANTES/CCL5 as determined by LAL method.

Storage:-20ºC

Sequence:SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS

uniprot accession:P1351

Molecular weight:Approximately 7.8 kDa, a single non-glycosylated polypeptide chain containing 68 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2mM PB, pH 7.4, 1 mM NaCl.