Recombinant Human PPIase/FKBP7 Protein (aa 1-218, His Tag)

SKU: PKSH030674

Size: 100μg

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation:

Target Synonym: 23 kDa FK506-Binding Protein;23 kDa FKBP;FK506-Binding Protein 7;FKBP-23;FKBP-7;FKBP23;FKBP7;PPIase FKBP7;Peptidyl-Prolyl Cis-Trans Isomerase FKBP7;Rotamase

Research Areas: Signal Transduction;epigenetics and nuclear signal;immunology;

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application:

Fusion tag: C-His

UNIProt ID: Q9Y3C6

Accession: Q9Y3C6

Background: PPIase is a member of the immunophilin protein family. It also belongs to the cyclophilin-type PPIase family; PPIL3 subfamily. PPIase contains 1 PPIase cyclophilin-type domain. Members of the immunophilin protein family play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. It has a very high substrate specificity for the four-residue peptide Ala-Ala-Pro-Phe only when the proline peptide bond is in the trans state. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels; and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse; deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.

Concentration:

Activity: Not validated for activity

Sequence: Met 1-Gln218

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 23.8 kDa

ObservedMW: 27-30 kDa