Recombinant Human MDC/CCL22 protein

SKU: CD01310

Size:5 ug

Background:CCL22 is a protein that in humans is encoded by the CCL22 gene, which locates on the Chr. 16. The protein is highly expressed in macrophage, monocyte-derived dendritic cell and thymus, additionally, also detected in the tissues of thymus, lymph node and appendix. CCL22 can bind to CCR4, and is a chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells, but not for neutrophils, eosinophils, and resting T-lymphocytes. After secreted from monocyte-derived dendritic cells, the protein can be proteolytic cleaved into three forms: MDC (3-69), MDC (5-69), MDC (7-69).

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Macrophage-Derived Chemokine/CCL22

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 1-1 ng/ml.

Synonyms:MDC/CCL22,A-152E5.1, ABCD-1, DC/B-CK, MDC, SCYA22, STCP-1, Human

Endotoxin:Less than 1 EU/μg of rHuMDC/CCL22 as determined by LAL method.

Storage:-20ºC

Sequence:GPYGANMEDS VCCRDYVRYR LPLRVVKHFY WTSDSCPRPG VVLLTFRDKE ICADPRVPWV KMILNKLSQ

uniprot accession:O626

Molecular weight:Approximately 8.1 kDa, a single, non-glycosylated polypeptide chain containing 69 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 mM PB, pH7.4, 5 mM NaCl.