Recombinant Human MAN1B1 Protein (His Tag)

SKU: PKSH032400

Size: 50μg

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: MAN1B1

Target Synonym: 2-Alpha-Mannosidase;2-Mannosidase;ER Alpha-1;ER Mannosidase 1;ERMan1;Endoplasmic Reticulum Mannosyl-Oligosaccharide 1;MAN1B1;Man9GlcNAc2-Specific-Processing Alpha-Mannosidase;Mannosidase Alpha Class 1B Member 1

Research Areas: Tags & Cell Markers

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application:

Fusion tag: C-His

UNIProt ID: Q9UKM7

Accession: Q9UKM7

Background: Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.

Concentration:

Activity: Not validated for activity

Sequence: Asp106-Ala699

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl,10mM reduced Glutathione,pH 8.0.

Reconstitution: Not Applicable

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 68.7 kDa

ObservedMW: 58-80 kDa