Recombinant Human IGF-BP7 protein

SKU: CD01586

Size:5 ug

Background:Insulin-like Growth Factor-Binding Protein 7 (IGF-BP7) belongs to the IGFBP family, which are all cysteinerich proteins with conserved cysteine and have an IGFBP domain, a Kazal-like domain and an Ig-like C2-type domain. IGF-BP7 is expressed in a wide range of normal human tissues and it generally shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin. It plays a role in skeletal myogenesis by binding to IGF in a manner that inhibits IGF induced differentiation of skeletal myoblasts, without affecting IGF induced proliferation. Additionally, IGF-BP7 suppresses growth and colony formation of prostate and breast cancer cell lines through an IGF independent mechanism, which causes a delay in the G1 phase of the cell cycle, and increased apoptosis. Mature human IGF-BP7 contains 256 a.a. with one potential N-linked glycosylation site.

Research_area:Signal Transduction

Purity:> 95 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Insulin-like Growth Factor-Binding Protein 7

Biological activity:Testing in Progress.

Synonyms:IGF-BP7, AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1,IGFBP7,Human

Endotoxin:Less than 0.1 EU/μg of rHuIGF-BP7 as determined by LAL method.

Storage:-20ºC

Sequence:SSSDTCGPCE PASCPPLPPL GCLLGETRDA CGCCPMCARG EGEPCGGGGA GRGYCAPGME CVKSRKRRKG KAGAAAGGPG VSGVCVCKSR YPVCGSDGTT YPSGCQLRAA SQRAESRGEK AITQVSKGTC EQGPSIVTPP KDIWNVTGAQ VYLSCEVIGI PTPVLIWNKV KRGHYGVQRT ELLPGDRDNL AIQTRGGPEK HEVTGWVLVS PLSKEDAGEY ECHASNSQGQ AS

uniprot accession:Q1627

Molecular weight:Approximately 26.4 kDa, a single non-glycosylated polypeptide chain containing 256 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 mM Tris-HCl, pH 8.6, 15 mM NaCl.