Recombinant Human I-309/CCL1 protein

SKU: CD01627

Size:2 ug

Background:Chemokine (C-C motif) ligand 1 (CCL1) belongs to a family inflammatory cytokines and also known as chemokines. It is a small glycoprotein secreted by activated T cells with a molecular weight of approximately 8.5 kDa. CCL1 attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with a cell surface chemokine receptor called CCR8. Human CCL1 has been assumed to be a homologue of the mouse TCA3. While the two proteins share only approximately 42 % amino acid sequence identity, both chemokines contain an extra pair of cysteine residues not found in most other chemokines.

Research_area:Immunology

Purity:> 97% by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human I-309/CCL1

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 1-1 ng/ml.

Synonyms:I-39/CCL1,I-39, P5, SCYA1, SISe, TCA3, Human

Endotoxin:Less than 1 EU/μg of rHuI-309/CCL1 as determined by LAL method.

Storage:-20ºC

Sequence:SKSMQVPFSR CCFSFAEQEI PLRAILCYRN TSSICSNEGL IFKLKRGKEA CALDTVGWVQ RHRKMLRHCP SKRK

uniprot accession:P22362

Molecular weight:Approximately 8.6 kDa, a single, non-glycosylated polypeptide chain containing 74 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 mM PB, pH 7.4, 1 mM NaCl.