Recombinant Human GABA Protein (His & FcTag)

SKU: PKSH032465

Size: 50μg

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: GABA

Target Synonym: GABA(A) Receptor-Associated Protein;GABARAP;GABARAP Protein;HCG1987397 Isoform CRA_b

Research Areas:

Conjugation:

Target Species: Human

Expression Host: E.coli

Application:

Fusion tag: N-His & C-Fc

UNIProt ID: Q6IAW1

Accession: Q6IAW1

Background: Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. GABARAP clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development; differentiation; growth regulation and tissue remodeling in multicellular organisms. An important inhibitory neurotransmitter; GABA; acts on GABA receptors that are ubiquitously expressed in the CNS. GABARAP has been shown to play a important role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton.

Concentration:

Activity: Not validated for activity

Sequence: Met1-Leu117

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 20% Glycerol, pH 7.0.

Reconstitution: Not Applicable

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 43.2 kDa

ObservedMW: 50 kDa