Recombinant Human DPP4/DPPIV/CD26 Protein (Fc Tag)

SKU: PKSH033696

Size: 50μg

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: DPP4;DPPIV;CD26

Target Synonym: ADABP;ADCP-2;Adenosine deaminase complexing protein 2;DPP IV;Dipeptidyl peptidase 4;Dipeptidyl peptidase IV;T-cell activation antigen CD26

Research Areas: Cell biology;Cancer;immunology;metabolism;Stem cells

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application:

Fusion tag: N-Fc

UNIProt ID: P27487

Accession: P27487

Background: CD26 is a signal-anchor for type II membrane protein that belongs to the peptidase S9B family. CD26 is expressed specifically in lymphatic vessels but not in blood vessels in the skin; small intestine; esophagus; ovary; breast and prostate glands. It acts as a positive regulator of T-cell coactivation; by binding at least ADA; CAV1; IGF2R; and PTPRC. It’s binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM); the migration and invasion of endothelial cells into the ECM. It may be involved in the promotion of lymphatic endothelial cells adhesion; migration and tube formation. When overexpressed; it enhanced cell proliferation; a process inhibited by GPC3. It acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation; including many chemokines; mitogenic growth factors; neuropeptides and peptide hormones.

Concentration:

Activity: Not validated for activity

Sequence: Asn29-Pro766

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of PBS, pH7.4.

Reconstitution: Not Applicable

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 111.7 kDa

ObservedMW: 105-130 kDa