Recombinant Human CXCL7/NAP-2 Protein(Sumo Tag)

SKU: PDEH100572

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Immune Checkpoint Proteins

Abbreviation:CXCL7/NAP-2

Target Synonym:B-TG;CTAP;CXCL;SCYB;C-X-C Motif Chemokine;MDGFSmall-Inducible Cytokine B;LA-PF;NAP;PPBP;B-TG1;Beta-TG;CTAP-III;CTAP3;CTAPIII;CXCL7;LA-PF4;LDGF;MDGF;NAP-2;PBP;SCYB7;TC1;TC2;TGB;TGB1;THBGB;THBGB1;C-X-C Motif Chemokine 7;Leukocyte-Derived Growth Factor;Macrophage-Derived Growth Factor;MDGFSmall-Inducible Cytokine B7;NAP2;Platelet Basic Protein;βTG;B TG1;Beta TG;Beta thromboglobulin;beta-1;Chemokine (C X C motif) ligand 7;Connective tissue activating peptide III;CTAP 3;CTAP III;CTAP-III(1-81);CXC chemokine ligand 7;CXCL 7;LA PF 4;Leukocyte derived growth factor;Low-affinity platelet factor IV;NAP 2;NAP-2(1-63);NAP-2(1-66);NAP-2(73);NAP-2(74);Neutrophil activating peptide 2;Neutrophil-activating peptide 2(1-63);Pro platelet basic protein;Pro platelet basic protein (chemokine (C-X-C motif) ligand 7);Pro-Platelet basic protein;Small inducible cytokine subfamily B member 7;Small-inducible cytokine B7;Thrombocidin 1;Thrombocidin 2;Thromboglobulin;βTG;PBP;CXCL7;NAP2;β-thromboglobulin

Research Areas:Immunology;Cardiovascular;Signal Transduction

Conjugation:

Target Species:Human

Expression Host:E.coli

Application:

Fusion tag:N-Sumo

UNIProt ID:P02775

Accession:P02775

Background:Pro-platelet basic protein (PPBP) is also known as Chemokine (C-X-C motif) ligand 7 (CXCL7) and nucleosome assembly protein (Nap-2). Nap-2 / PPBP / CXCL7 is released in large amounts from platelets following their activation and is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. Nap-2 / PPBP / CXCL7 has been shown to stimulate various cellular processes including DNA synthesis , mitosis , glycolysis , intracellular cAMP accumulation , prostaglandin E2 secretion , and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Nap-2 is a ligand for CXCR1 and CXCR2 , and Nap-2 , Nap-2 (73) , Nap-2 (74) , Nap-2 (1-66) , and most potent Nap-2 (1-63) are chemoattractants and activators for neutrophils.

Concentration:

Activity:Not validated for activity

Sequence:Ala59-Asp128

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 10 EU/mg of the protein as determined by the LAL method.

Calculated MW:20.59 kDa

ObservedMW:25 kDa